Zapnometinib (ATR-002) | MEK inhibitor | Probechem Biochemicals

Chemical Structure : Zapnometinib

CAS No.: 303175-44-2

加入收藏

Zapnometinib (ATR-002, PD0184264)

货号: PC-38429Not For Human Use, Lab Use Only.

Zapnometinib (ATR-002, PD0184264) is the active metabolite of CI-1040, a novel MEK inhibitor (IC50=30.96 nM, cell free assay) with broad antiviral activity against different influenza virus strains, as well as SARS-CoV-2.

规格	价格	库存
10 mg	￥580	In stock
25 mg	￥880	In stock
50 mg	￥1280	In stock
100 mg	￥2180	In stock
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Zapnometinib (ATR-002, PD0184264) is the active metabolite of CI-1040, a novel MEK inhibitor (IC50=30.96 nM, cell free assay) with broad antiviral activity against different influenza virus strains, as well as SARS-CoV-2.
Zapnometinib (ATR-002, PD0184264) inhibits ERK-phosphorylation in human PBMCs and intracellular deposition.
Zapnometinib (ATR-002, PD0184264) exhibited antiviral effect against H1N1pdm09 or the H3N2 strain and on MDCK II cells with EC50 of 4.190-6.356 uM.
Zapnometinib (ATR-002, PD0184264) also efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses.

物理化学性质&存储条件

分子量	409.555
分子式	C13H7ClF2INO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-Chloro-4-iodo-phenylamino)-3,4-difluoro benzoic acid

参考文献

1. Bruchhagen C, et al. Sci Rep. 2018 Jun 14;8(1):9114.

2. Laure M, et al. Antiviral Res. 2020 Jun;178:104806.

3. Hamza H, et al. Front Microbiol. 2021 Feb 12;12:611958.

4. Schreiber A, et al. Cell Mol Life Sci. 2022 Jan 10;79(1):65.

Zapnometinib (ATR-002, PD0184264)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Zapnometinib (ATR-002, PD0184264)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.