Zanubrutinib (BGB3111) | BTK inhibitor | Probechem Biochemicals

Chemical Structure : Zanubrutinib

CAS No.: 1691249-45-2

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Zanubrutinib ((S)-Zanubrutinib, BGB3111, BGB 3111)

货号: PC-60535Not For Human Use, Lab Use Only.

Zanubrutinib (BGB3111) is a potent, selective and orally available Btk inhibitor with IC50 of 0.3 nM.

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5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
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生物&药学活性

Zanubrutinib (BGB3111) is a potent, selective and orally available Btk inhibitor with IC50 of 0.3 nM.
Zanubrutinib (BGB3111) shows much more restricted off-target activities against a panel of kinases, including ITK, compared with Ibrutinib.
Zanubrutinib (BGB3111) demonstrates nanomolar BTK inhibition activity, inhibits BCR aggregation-triggered BTK autophosphorylation, blocks downstream PLC-γ2 signaling, and potently inhibits cell proliferation in several MCL and DLBCL cell lines.
Zanubrutinib (BGB3111) demonstrates better anti-tumor activity than ibrutinib in TMD-8 subcutaneous xenograft model.

物理化学性质&存储条件

分子量	471.561
分子式	C27H29N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(7S)-4,5,6,7-Tetrahydro-7-[1-(1-oxo-2-propen-1-yl)-4-piperidinyl]-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

参考文献

1. Na Li, et al. Abstract 2597: BGB-3111 is a novel and highly selective Bruton's tyrosine kinase (BTK) inhibitor. AACR.

Zanubrutinib ((S)-Zanubrutinib, BGB3111, BGB 3111)

生物&药学活性

物理化学性质&存储条件

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Zanubrutinib ((S)-Zanubrutinib, BGB3111, BGB 3111)

生物&药学活性

物理化学性质&存储条件

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