Zandelisib (ME-401, PWT-143)

Chemical Structure : Zandelisib

CAS No.: 1401436-95-0

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货号: PC-20568Not For Human Use, Lab Use Only.

Zandelisib (ME-401, PWT-143) is a potent, selective and orally active inhibitor of phosphatidylinositol 3 kinase (PI3K) p110δ with IC50 of 3.5 nM.

规格	价格	库存
5 mg	￥1480	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Zandelisib (ME-401, PWT-143) is a potent, selective and orally active inhibitor of phosphatidylinositol 3 kinase (PI3K) p110δ with IC50 of 3.5 nM.
Zandelisib inhibits PI3Ks with IC50s of 4, 976 nM, 605 nM, 817 nM and 3.5 nM for p110α, p110β, p110γ and p110δ, respectivey.

物理化学性质&存储条件

分子量	576.68
分子式	C31H38F2N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-N-(2-methyl-1-(2-(1-methylpiperidin-4-yl)phenyl)propan-2-yl)-6-morpholino-1,3,5-triazin-2-amine

参考文献

1. Moreno O, et al. Clin Ther. 2018 Nov;40(11):1855-1867.

2. Patent WO2019183226A1.