Zanapezil |CAS:263248-42-6 Probechem Biochemicals

Chemical Structure : Zanapezil

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Zanapezil (TAK-147;TAK147)

货号: PC-63361Not For Human Use, Lab Use Only.

Zanapezil (TAK-147) is a potent, selective acetylcholinesterase (AChE) inhibitor with IC50 of 97.7 nM.

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生物&药学活性

Zanapezil (TAK-147) is a potent, selective acetylcholinesterase (AChE) inhibitor with IC50 of 97.7 nM。
Zanapezil (TAK-147) ameliorates the passive avoidance deficit induced by diazepam in animal models at 1-3 mg/kg。
Zanapezil (TAK-147) ameliorates the impairment of DMTP performance induced by scopolamine without affecting the general behavior of the rats.

物理化学性质&存储条件

分子量	492.616
分子式	C29H36N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1- benzazepin-8-yl)-1-propanone fumarate

参考文献

1. Hatip-Al-Khatib I, et al. Br J Pharmacol. 2005 Aug;145(8):1035-44.

2. Hirai K, et al. J Pharmacol Exp Ther. 1997 Mar;280(3):1261-9.

3. Miyamoto M, et al. J Pharmacol Exp Ther. 1996 Jun;277(3):1292-304.

4. Ishihara Y, et al. J Med Chem. 1994 Jul 22;37(15):2292-9.

Zanapezil (TAK-147;TAK147)

生物&药学活性

物理化学性质&存储条件

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Zanapezil (TAK-147;TAK147)

生物&药学活性

物理化学性质&存储条件

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