Zanamivir

Chemical Structure : Zanamivir

CAS No.: 139110-80-8

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货号: PC-43395Not For Human Use, Lab Use Only.

Zanamivir is a highly potent, broad-spetrum influenza viral neuraminidase (NA) inhibitor with IC50 of 0.95 nM and 2.7 nM for influenza A and B, respectively.

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25 mg	￥380	In stock
100 mg	￥880	In stock
250 mg	￥1380	In stock
1 g	￥2580	In stock
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生物&药学活性

Zanamivir is a highly potent, broad-spetrum influenza viral neuraminidase (NA) inhibitor with IC50 of 0.95 nM and 2.7 nM for influenza A and B, respectively.
Zanamivir inhibits plaque formation by laboratory-passaged strains of influenza A and B viruses,IC50 ranging from 0.005 to 0.014 uM.
Zanamivir interacts with a group of amino acids in the active site of neuraminidase, which are conserved in all influenza A and B strains.
Zanamivir blocks the action of neuraminidase, which prevents the cleavage of sialic acid on the cell receptors, thus preventing release and spread of the newly formed virions.

物理化学性质&存储条件

分子量	332.3098
分子式	C12H20N4O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	H2O: ≥ 33.33 mg/mL
Chemical Name/SMILES	D-glycero-D-galacto-Non-2-enonic acid, 5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-

参考文献

1. Woods JM, et al. Antimicrob Agents Chemother. 1993 Jul;37(7):1473-9.

2. Gubareva LV, et al. Antimicrob Agents Chemother. 2001 Dec;45(12):3403-8.

3. McKimm-Breschkin JL, et al. Treat Respir Med. 2005;4(2):107-16.

4. Ryan DM, et al. Antimicrob Agents Chemother. 1994 Oct;38(10):2270-5.

Zanamivir

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