ZZW-115 | NUPR1 inhibitor | Probechem Biochemicals

Chemical Structure : ZZW-115

CAS No.: 801991-87-7

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ZZW-115 (ZZW115;ZZW 115)

货号: PC-36152Not For Human Use, Lab Use Only.

ZZW-115 (ZZW115, ZZW 115) is a potent inhibitor of NUPR1 (Kd=2.1 uM), an intrinsically disordered protein (IDP) with an entirely disordered conformation.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ZZW-115 (ZZW115, ZZW 115) is a potent inhibitor of NUPR1 (Kd=2.1 uM), an intrinsically disordered protein (IDP) with an entirely disordered conformation.
ZZW-115 demonstrates antitumor activity on a panel of 11 primary PDAC-derived cells and it was found to be efficient to kill the cancer cells with IC50 in the range from 0.84 μM (ANOR) to 4.93 μM (HN14).
ZZW-115 also inhibits the growth of other tumors-derived cells (IC50=0.42 μM (Hep2G cells) to 7.75 μM (SaO-2 cells)).
ZZW-115 induces pancreatic cell death by necrosis and apoptosis and inhibits the growth pancreatic xenografted tumors in vivo.

物理化学性质&存储条件

分子量	464.595
分子式	C24H31F3N4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO : 46.5 mg/mL (100 mM, Ultrasonic needed) H2O : 146.5 mg/mL (100 mM, Ultrasonic needed)
Chemical Name/SMILES	N,N-dimethyl-2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethan-1-amine

参考文献

1. Santofimia-Castaño P, et al. J Clin Invest. 2019 Mar 28;130. pii: 127223.

ZZW-115 (ZZW115;ZZW 115)

生物&药学活性

物理化学性质&存储条件

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ZZW-115 (ZZW115;ZZW 115)

生物&药学活性

物理化学性质&存储条件

参考文献

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