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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-ZZM-1220
ZZM-1220

Chemical Structure : ZZM-1220

CAS No.: 3053365-97-9

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ZZM-1220 (ZZM1220)

货号: PC-23902Not For Human Use, Lab Use Only.

ZZM-1220 is a potent, selective G9a/GLP covalent inhibitor with IC50 of 458/924 nM respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ZZM-1220 is a potent, selective G9a/GLP covalent inhibitor with IC50 of 458/924 nM respectively.
ZZM-1220 exhibits antiproliferative activity on MDA-MB-231 with IC50 of 0.59 uM, induces apoptosis of TNBC cells.
ZZM-1220 arrests MDA-MB-231 and 4T1 cells in the G2/M phase.
ZZM-1220 (2.5-20 uM) significantly inhibits H3K9 dimethylation in a concentration-dependent manner in in MDA-MB-231 cells.
ZZM-1220 continuously inhibits the proliferation of cancer cells and the methylation function of G9a/GLP after washing out.

物理化学性质&存储条件

分子量 449.56
分子式 C25H31N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-(6,7-dimethoxy-4-((1-methylpiperidin-4-yl)amino)quinazolin-2-yl)phenyl) propionamide

参考文献

1. Zhang Q, et al. Eur J Med Chem. 2023 Dec 5;261:115841.

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