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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-ZYTP1
ZYTP1

Chemical Structure : ZYTP1

CAS No.: 1616891-07-6

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ZYTP1 (PARP inhibitor ZYTP1)

货号: PC-35506Not For Human Use, Lab Use Only.

ZYTP1 is a novel, oral PARP inhibitor that inhibits PARP1, PARP2, Tankyrase-1 and Tankyrase-2 with IC50 of 5.4, 0.7, 133.3 and 289.8 nM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ZYTP1 is a potent, oral PARP inhibitor that inhibits PARP1, PARP2, Tankyrase-1 and Tankyrase-2 with IC50 of 5.4, 0.7, 133.3 and 289.8 nM, respectively.
    ZYTP1 potentiates MMS mediated cell killing of cancer cells in vitro (SW620 PF50=6.4).
    ZYTP1 displays potent antitumor activity in BRCA-deficient models and potentiated the activity of other conventional chemotherapeutic drugs.

    物理化学性质&存储条件

    分子量 431.471
    分子式 C24H22FN5O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(4-fluoro-3-(2-isopropyl-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-5-carbonyl)benzyl)phthalazin-1(2H)-one

    参考文献

    1. Jain MR, et al. Cancer Chemother Pharmacol. 2018 Jul 25. doi: 10.1007/s00280-018-3653-1.

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