ZYF0033 | HPK1 inhibitor | Probechem Biochemicals

Chemical Structure : ZYF0033

CAS No.: 2380300-79-6

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ZYF0033 (ZYF-0033)

货号: PC-72305Not For Human Use, Lab Use Only.

ZYF0033 (ZYF 0033) is potent, selective, small-molecule inhibitor of HPK1 (MAP4K1) with IC50 of <10 nM based on the phosphorylation inhibition of MBP protein.

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5 mg	￥1780	In stock
10 mg	￥2880	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

ZYF0033 (ZYF 0033) is potent, selective, small-molecule inhibitor of HPK1 (MAP4K1) with IC50 of <10 nM based on the phosphorylation inhibition of MBP protein.
ZYF0033 successfully decreased the phosphorylation of SLP76 (serine 376), a critical biomarker of T cell and HPK1 activation.
ZYF0033 promoted anticancer immune responses, inhibited tumor growth and caused increased intratumoral infiltration of DCs, NK cells, and CD107a+CD8+ T cells but decreased infiltration of regulatory T cells, PD-1+CD8+ T cells, TIM-3+CD8+ T cells, and LAG-3+CD8+ T cells in the 4T-1 syngeneic mouse model.
ZYF0033 significantly increased the proliferation of CD4+ and CD8+ T cells (Figure S7I) and the secretion of IFN-γ in bone-marrow-derived DCs.

物理化学性质&存储条件

分子量	462.612
分子式	C26H30N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Butyn-2-ol, 4-[3-[[[2-amino-5-[2-(1-methyl-4-piperidinyl)-5-thiazolyl]-3-pyridinyl]oxy]methyl]phenyl]-2-methyl-

参考文献

1. Jingwen Si, et al. Cancer Cell. 2020 Oct 12;38(4):551-566.e11.

ZYF0033 (ZYF-0033)

生物&药学活性

物理化学性质&存储条件

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ZYF0033 (ZYF-0033)

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