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首页-小分子抑制剂&激动剂-Others-Other Targets-ZY-444
ZY-444

Chemical Structure : ZY-444

CAS No.: 1802650-31-2

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ZY-444 (ZY444)

货号: PC-47056Not For Human Use, Lab Use Only.

ZY-444 is a specific metabolic inhibitor of pyruvate carboxylase, a key anaplerotic enzyme of the tricarboxylic acid cycle (TCA cycle), suppresses breast cancer growth and metastasis through inhibiting the Wnt/β‐catenin/Snail signaling pathway.

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5 mg ￥2180 In stock
10 mg ￥3480 In stock
25 mg ￥5480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ZY-444 is a specific metabolic inhibitor of pyruvate carboxylase, a key anaplerotic enzyme of the tricarboxylic acid cycle (TCA cycle), suppresses breast cancer growth and metastasis through inhibiting the Wnt/β‐catenin/Snail signaling pathway.
ZY‐444 displayed potent efficacy against cancer proliferation and invasion but much less toxicity to normal cells.
ZY‐444 selectively inhibited invasive breast cancer (BCA) proliferation (IC90=5 uM), migration, and invasion.
ZY‐444 suppressed BCA growth, metastasis, and lung colonization in vivo.
ZY‐444 is an inhibitor of pyruvate carboxylase (PC) by binding to and inhibiting its enzymatic activity without influencing PC expression.
ZY‐444 inhibited the Wnt signaling pathway in MDA‐MB‐231 cells.

物理化学性质&存储条件

分子量 444.597
分子式 C26H28N4OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N4-((5-(4-(benzyloxy)phenyl)thiophen-2-yl)methyl)-N2-isobutylpyrimidine-2,4-diamine

参考文献

1. Qingxiang Lin, et al. Adv Sci (Weinh). 2020 Mar 12;7(9):1903483.

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