ZW-2038 | Orthopoxvirus inhibitor | Probechem Biochemicals

Chemical Structure : ZW-2038

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ZW-2038 (ZW2038)

货号: PC-27149Not For Human Use, Lab Use Only.

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200 mg		Get quote

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生物&药学活性

ZW-2038 is a potent antiviral compound against orthopoxviruses vaccinia virus (VACV), monkeypox virus (MPXV), and cowpox virus (CPXV), inhibits VACV replication inhibitor in primary HFFs with EC50 of 876 nM.
ZW-2038 suppresses VACV DNA replication and downstream gene expression but not early gene replication, suppresses VACV replication by interfering with VACV DNA replication, which in turn prevents the expression of downstream intermediate and late genes.
ZW-2038 (10 μM) significantly inhibits MPXV and CPXV replication in primary HFFs.
ZW-2038 reduces VACV replication in human and non-human primate enteroids and in ex vivo lung tissue models.
ZW-2038 does not inhibit MPXV resolvase in vitro.

物理化学性质&存储条件

分子量	402.37
分子式	C21H17F3N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2,4-difluorophenethyl)-1-(4-fluorobenzyl)-5-hydroxy-4-oxo-1,4-dihydropyridine-3-carboxamide

参考文献

1. Pant A, et al. Antimicrob Agents Chemother. 2026 Jun 18:e0192225.

2. Senaweera S, et al. Acta Pharm Sin B 12:1671–1684.

ZW-2038 (ZW2038)

生物&药学活性

物理化学性质&存储条件

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ZW-2038 (ZW2038)

生物&药学活性

物理化学性质&存储条件

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