ZW-1226 | MRP1 inhibitor | Probechem Biochemicals

Chemical Structure : ZW-1226

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ZW-1226 (ZW1226)

货号: PC-22756Not For Human Use, Lab Use Only.

ZW-1226 is a deazaflavin analog and potent inhibitor of multidrug resistance-associated protein 1 (MRP1), inhibits MRP1-mediated E217βG uptake with IC50 of 0.5 uM in vesicular transport assay.

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生物&药学活性

ZW-1226 is a deazaflavin analog and potent inhibitor of multidrug resistance-associated protein 1 (MRP1), inhibits MRP1-mediated E217βG uptake with IC50 of 0.5 uM in vesicular transport assay.
ZW-1226 is 16 times more potent than the known MRP1 inhibitor MK-571 in vesicular transport assay.
ZW-1226 shows good selectivity for MRP1 over other major ABC transporters, including P-gp, BCRP, MRP2 and MRP3.
ZW-1226 effectively reversed MRP1-mediated drug resistance to TOP2 poisons etoposide and doxorubicin in H69AR cells.
ZW-1226 exhibited high tissue to plasma partitioning in mice without altering etoposide distribution to normal tissues.

物理化学性质&存储条件

分子量	422.44
分子式	C25H18N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	10-(4-(benzyloxy)phenyl)-2,4-dioxo-2,3,4,4a,5,10-hexahydropyrimido[4,5-b]quinoline-8-carbonitrile

参考文献

1. Belhadj Z, et al. Biomed Pharmacother. 2024 Jul 19;178:117167.

ZW-1226 (ZW1226)

生物&药学活性

物理化学性质&存储条件

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ZW-1226 (ZW1226)

生物&药学活性

物理化学性质&存储条件

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