ZTM000990 |CAS:115834-23-6 Probechem Biochemicals

Chemical Structure : ZTM000990

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ZTM000990 (SF 2446A1)

货号: PC-61810Not For Human Use, Lab Use Only.

ZTM000990 is a small-molecule antagonist of the oncogenic Tcf4/β-catenin protein complex with IC50 of 0.64 uM.

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生物&药学活性

ZTM000990 is a small-molecule antagonist of the oncogenic Tcf4/β-catenin protein complex with IC50 of 0.64 uM.
ZTM000990 reduces levels of either c-Myc or cyclin D1 in HCT116 cells without effect on cyclin E level.
ZTM000990 shows effects on growth of colon and prostate cancer cell lines (IC50=0.15-0.3 uM).

物理化学性质&存储条件

分子量	697.646
分子式	C34H35NO15
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzo[a]naphthacene-2-carboxylic acid, 11-[(6-deoxy-2,4-di-O-methyl-b-L-mannopyranosyl)amino]-5,6,6a,7,9,12,14,14a-octahydro-1,6,8,14a-tetrahydroxy-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-, methyl ester, (6R,6aS,14aR)-

参考文献

1. Lepourcelet M, et al. Cancer Cell. 2004 Jan;5(1):91-102.

2. Katoh M, et al. Clin Cancer Res. 2007 Jul 15;13(14):4042-5.

ZTM000990 (SF 2446A1)

生物&药学活性

物理化学性质&存储条件

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ZTM000990 (SF 2446A1)

生物&药学活性

物理化学性质&存储条件

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