ZTA-261 (ZTA261)

Chemical Structure : ZTA-261

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货号: PC-24488Not For Human Use, Lab Use Only.

ZTA-261 is a thyroid hormone analog and selective agonist agonist of thyroid hormone receptor beta-subtype (TRβ, THRβ) with IC50 of 6.3 nM, >100-fold selective over TRα.

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生物&药学活性

ZTA-261 is a thyroid hormone analog and selective agonist agonist of thyroid hormone receptor beta-subtype (TRβ, THRβ) with IC50 of 6.3 nM, >100-fold selective over TRα.
ZTA-261 is more selective towards THRβ than GC-1. effective as GC-1 in reducing the levels of serum and liver lipids.
ZTA-261 significantly increased Dio1 and Me1 expression, also upregulated Thrsp.
ZTA-261 at 1 µmol/kg·day reduced fat droplets to a level comparable to that in animals fed a normal diet.

物理化学性质&存储条件

分子量	428.33
分子式	C21H14F6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzeneacetic acid, 4-[(4-hydroxy-1-naphthalenyl)methyl]-3,5-bis(trifluoromethyl)-

参考文献

1. Nambo M, et al. Commun Med (Lond). 2024 Aug 6;4(1):152.

ZTA-261 (ZTA261)

生物&药学活性

物理化学性质&存储条件

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ZTA-261 (ZTA261)

生物&药学活性

物理化学性质&存储条件

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