ZT55 | JAK2 inhibitor | Probechem Biochemicals

Chemical Structure : ZT55

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ZT55 (JAK2 inhibitor ZT55)

货号: PC-36069Not For Human Use, Lab Use Only.

ZT55 (JAK inhibitor ZT55) is a novel potent, highly-selective tyrosine kinase JAK2 inhibitor with IC50 of 31 nM.

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生物&药学活性

ZT55 (JAK inhibitor ZT55) is a novel potent, highly-selective tyrosine kinase JAK2 inhibitor with IC50 of 31 nM.
ZT55 displays no significant activity against JAK1/3 (IC50>10 uM).
ZT55 exhibits potent effects on the cellular JAK-STAT pathway, inhibiting tyrosine phosphorylation in JAK2V617F and downstream STAT3/5 transcription factors.
ZT55 inhibits the proliferation of the JAK2V617F-expressing HEL cell line, leading to cell cycle arrest at the G2/M phase and induction of caspase-dependent apoptosis.
ZT55 significantly suppressed the growth of HEL xenograft tumors in vivo, blocks erythroid colony formation of peripheral blood hematopoietic progenitors from patients carrying the JAK2V617F mutation.

物理化学性质&存储条件

分子量	296.326
分子式	C17H16N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1-hydroxy-1H-indol-3-yl)-N-(2-methoxyphenyl)acetamide

参考文献

1. Hu M, et al. J Exp Clin Cancer Res. 2019 Feb 4;38(1):49.

ZT55 (JAK2 inhibitor ZT55)

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ZT55 (JAK2 inhibitor ZT55)

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