ZT-1a | SPAK (STK39) inhibitor | Probechem Biochemicals

Chemical Structure : ZT-1a

CAS No.: 212135-62-1

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ZT-1a (STK39 inhibitor ZT-1a, SPAK-IN-ZT-1a)

货号: PC-72593Not For Human Use, Lab Use Only.

ZT-1a (STK39 inhibitor ZT-1a, SPAK-IN-ZT-1a) is a novel potent, selective SPAK kinase (STK39) inhibitor.

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5 mg	￥2780	In stock
10 mg	￥4580	In stock
25 mg	￥7980	In stock
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100 mg		Get quote

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生物&药学活性

ZT-1a (STK39 inhibitor ZT-1a, SPAK-IN-ZT-1a) is a novel potent, selective SPAK kinase (STK39) inhibitor.
ZT-1a potently inhibited SLC12A cation-Cl-cotransporters (CCC), phosphorylation of NKCC1 p-Thr203/207/212 by 72% at 1uM and phosphorylation of KCC sites 1/2 by 65-77% at 3 uM in HEK-293 cells.
ZT-1a is a more potent modulator of SPAK-dependent CCC phosphorylation than the current SPAK kinase inhibitors Closantel, STOCK1S-50699, and STOCK1S-14279.
ZT-1a inhibited SPAK phosphorylation at Ser373 in HEK-293 cells (70% inhibition at 3-10 uM).
ZT-1a disrupts SPAK interaction with WNK but not with MO25α, reduces SPAK-dependent CCC phosphorylation in cells, inhibits NKCC1 but stimulates KCC3 activity.
ZT-1a decreases SPAK-CCC phosphorylation in hemorrhagic hydrocephalus, modulates primary cortical neuron volume, reduces stroke-associated cerebral edema and infarct, improves neurological function after ischemic stroke in vivo.

物理化学性质&存储条件

分子量	445.73
分子式	C22H15Cl3N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-chloro-N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxybenzamide

参考文献

1. Jinwei Zhang, et al. Nat Commun. 2020 Jan 7;11(1):78.

ZT-1a (STK39 inhibitor ZT-1a, SPAK-IN-ZT-1a)

生物&药学活性

物理化学性质&存储条件

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ZT-1a (STK39 inhibitor ZT-1a, SPAK-IN-ZT-1a)

生物&药学活性

物理化学性质&存储条件

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