ZT-12-037-01

Chemical Structure : ZT-12-037-01

CAS No.: 2328073-61-4

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货号: PC-36062Not For Human Use, Lab Use Only.

ZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor with IC50 of 20.04 nM measured as percentage of NRAS phosphorylation.

规格	价格	库存
5 mg	￥680	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg	￥5480	In stock
250 mg		Get quote

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生物&药学活性

ZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor with IC50 of 20.04 nM measured as percentage of NRAS phosphorylation.
ZT-12-037-01 shows similar IC50 of 23.96 and 27.94 nM for STK19WTWT STK19D89N respectively.
ZT-12-037-01 displays extremely high kinase selectivity using KINOMEscan against a panel of 468 diverse kinases using an in vitro ATP-site competition binding assay at 1 uM.
ZT-12-037-01 efficiently inhibits phosphorylation of NRAS in a dose- and time-dependent manner, inhibits NRAS activity in a dose-dependent manner but does not affect the levels of H3K9 methylation.
ZT-12-037-01 effectively inhibits NRAS signaling, including the MEK-ERK and PI3K pathways in SK-MEL-2 and WM2032 cells (with NRASQ61R), but the inhibition was much less effective in A375 or UACC62 cells (with NRASWT), effectively inhibits cell growth and induces apoptosis of SK-MEL-2 and WM2032 melanoma cells.

物理化学性质&存储条件

分子量	385.512
分子式	C21H31N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N2-cyclopropyl-N4-(1-isopropylpiperidin-4-yl)-6,7-dimethoxyquinazoline-2,4-diamine

参考文献

1. Yin C, et al. Cell. 2019 Jan 24. pii: S0092-8674(19)30035-2. doi: 10.1016/j.cell.2019.01.002.

ZT-12-037-01

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