ZSP1601 | PDE inhibitor | Probechem Biochemicals

Chemical Structure : ZSP1601

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ZSP1601 (ZSP-1601)

货号: PC-28425Not For Human Use, Lab Use Only.

ZSP1601 is a non-selective, pan-phosphodiesterase (PDE) inhibitor with IC50 of 2.82 uM, exerts anti-inflammatory activities.

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生物&药学活性

ZSP1601 is a non-selective, pan-phosphodiesterase (PDE) inhibitor with IC50 of 2.82 uM, exerts anti-inflammatory activities.
ZSP1601 can increse the intracellular concentration of cAMP to suppress the synthesis of tumor necrosis factor alpha (TNF-α), a pro-inflammatory cytokine that induces inflammation and hepatocellular damage in NASH.
ZSP1601 has inhibitory effects on other subsets of PDE, including PDE1A, PDE4B, and PDE5A.

物理化学性质&存储条件

分子量	346.43
分子式	C18H26N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Purine-2,6-dione, 7-(cyclopropylmethyl)-3,7-dihydro-1-[(cis-4-hydroxy-4-methylcyclohexyl)methyl]-3-methyl-

参考文献

1. Li H, et al. Eur J Pharm Sci. 2024 Aug 1;199:106808.

2. Hu Y, et al. Nat Commun. 2023 Oct 12;14(1):6409.

ZSP1601 (ZSP-1601)

生物&药学活性

物理化学性质&存储条件

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ZSP1601 (ZSP-1601)

生物&药学活性

物理化学性质&存储条件

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