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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Polo-like Kinase (PLK)-ZSL-M028
ZSL-M028

Chemical Structure : ZSL-M028

CAS No.:

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ZSL-M028

货号: PC-27332Not For Human Use, Lab Use Only.

ZSL-M028 is a potent and selective, orally active Polo-like kinase 4 (PLK4) inhibitor with IC50 of 1.1 nM, has 1600-fold selectivity over Aurora A, demonstrates significant in vitro and in vivo antitumor activity against TRIM37-amplified neuroblastoma.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ZSL-M028 is a potent and selective, orally active Polo-like kinase 4 (PLK4) inhibitor with IC50 of 1.1 nM, has 1600-fold selectivity over Aurora A, demonstrates significant in vitro and in vivo antitumor activity against TRIM37-amplified neuroblastoma.

物理化学性质&存储条件

分子量 505.53
分子式 C27H29FN5O2P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-fluoro-2-(((2-((4-morpholinophenyl)amino)quinazolin-7-yl)amino)methyl)phenyl)dimethylphosphine oxide

参考文献

1. Liu N, et al. J Med Chem. 2026 Jul 16. doi: 10.1021/acs.jmedchem.6c01348.

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