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首页-小分子抑制剂&激动剂-Tyrosine Kinase-DYRK-ZRMQ-22
ZRMQ-22

Chemical Structure : ZRMQ-22

CAS No.:

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ZRMQ-22 (ZRMQ22)

货号: PC-26298Not For Human Use, Lab Use Only.

ZRMQ-22 is a highly potent DYRK1A inhibitor with IC50 of 0.35 nM, concentration-dependently inhibits nitric oxide (NO) production in LPS-stimulated BV2 cells with IC50 of 1 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ZRMQ-22 is a highly potent DYRK1A inhibitor with IC50 of 0.35 nM, concentration-dependently inhibits nitric oxide (NO) production in LPS-stimulated BV2 cells with IC50 of 1 uM.
ZRMQ-22 (1 uM) significantly suppressed the secretion of pro-inflammatory cytokines TNF-α and IL-6, with inhibition rates of 64.99% and 114.35%, respectively.
ZRMQ-22 effectively reduced levels of inflammatory markers and improved cognitive function in an LPS-induced neuroinflammation mouse model using C57BL/6 mice.

物理化学性质&存储条件

分子量 436.52
分子式 C26H24N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(5-(2-methoxypyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-(piperidin-1-yl)quinazoline

参考文献

1. Ren M, et al. RSC Med Chem. 2026 Feb 20. doi: 10.1039/d6md00007j.

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