ZQ-16 |CAS:376616-73-8 Probechem Biochemicals

Chemical Structure : ZQ-16

CAS No.: 376616-73-8

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ZQ-16 (ZQ 16;ZQ16)

货号: PC-60642Not For Human Use, Lab Use Only.

ZQ-16 is a potent and selective agonist of GPR84 that induces calcium response with EC50 of 0.213 uM.

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生物&药学活性

ZQ-16 is a potent and selective agonist of GPR84 that induces calcium response with EC50 of 0.213 uM.
ZQ-16 does not evoke calcium responses in HEK293 cells expressing other FFARs, including GPR40, GPR41, GPR119, and GPR120.
ZQ-16 increases in intracellular calcium concentrations in HEK293/Gα16/GPR84 cells with EC50 of 1.01 uM.
ZQ-16 activates several GPR84-mediated signaling pathways, including calcium mobilization, inhibition of cAMP accumulation, phosphorylation of ERK1/2, receptor desensitization and internalization, and receptor-β-arrestin interaction.
ZQ-16 reduces forskolin-stimulated cAMP accumulation in HEK293 cells with EC50 of 0.134 uM.

物理化学性质&存储条件

分子量	228.31
分子式	C10H16N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(hexylthio)pyrimidine-4,6-diol

参考文献

1. Zhang Q, et al. J Pharmacol Exp Ther. 2016 May;357(2):337-44.

2. Liu Y, et al. ACS Med Chem Lett. 2016 Mar 30;7(6):579-83.

ZQ-16 (ZQ 16;ZQ16)

生物&药学活性

物理化学性质&存储条件

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ZQ-16 (ZQ 16;ZQ16)

生物&药学活性

物理化学性质&存储条件

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