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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-ZNL-05-044
ZNL-05-044

Chemical Structure : ZNL-05-044

CAS No.: 3034411-38-3

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ZNL-05-044 (CDK11 inhibitor)

货号: PC-38750Not For Human Use, Lab Use Only.

ZNL-05-044 is a potent, selective CDK11 inhibitor with Kd of 69 nM (CDK11A), shows significantly kinome-wide selectivity.

规格 价格 库存 数量
5 mg ￥2580 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ZNL-05-044 is a potent, selective CDK11 inhibitor with Kd of 69 nM (CDK11A), shows significantly kinome-wide selectivity.
ZNL-05-044 treatment leads to G2/M cell cycle arrest, impacts CDK11-dependent mRNA splicing in cells.

物理化学性质&存储条件

分子量 477.408
分子式 C21H22Cl2N6OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-amino-2-((2-methyl-6-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)thiazol-5-yl)(2,6-dichlorophenyl)methanone

参考文献

1. Li Z, et al. Eur J Med Chem. 2022 May 8;238:114433.

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