ZNF207 inhibitor C16

Chemical Structure : ZNF207 inhibitor C16

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货号: PC-21828Not For Human Use, Lab Use Only.

ZNF207 inhibitor C16 is a small molecule inhibitor of Zinc Finger Protein 207 (ZNF207) with binding KD of 67 nM (SPR assays), inhibits glioma cancer cell stemness.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

ZNF207 inhibitor C16 is a small molecule inhibitor of Zinc Finger Protein 207 (ZNF207) with binding KD of 67 nM (SPR assays), inhibits glioma cancer cell stemness.
ZNF207 inhibitor C16 exhibits antiproliferative activity against glioma cells, has broad anticancer potential against cervical cancer (Hela), leukemia (U-937), NSCLC (A549 and H460), and stomach adenocarcinoma (MKN45 and AGS) cell lines (IC50 = 3.84-15.64 μM).
ZNF207 inhibitor C16 shows IC50 of 0.74, 1.23, 2.10, and 0.87 μM for H4, LN229, HS683, and U251MG cells for sphere-formation inhibition, respectively.
ZNF207 inhibitor C16 inhibits different stemness-related gene expressions in different glioma cells (EpCAM, OCT4, c-Myc, CD24, NANOG, SOX2, CD133, and BMI-1).
ZNF207 inhibitor C16 (15 or 45 mg/kg, oral) demonstrates in vivo antitumor efficacy of C16 in glioma subcutaneous models.

物理化学性质&存储条件

分子量	554.53
分子式	C32H32BrN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(1-Benzylpiperidin-4-yl)ethyl)-9-bromo-12-cyano-9,10-dihydro-9,10-ethanoanthracene-12-carboxamide

参考文献

1. Menghan Zhang, et al. J Med Chem. 2024 Feb 20. doi: 10.1021/acs.jmedchem.3c02241.