ZN148 | Metallo-β-lactamase inhibitor | Probechem Biochemicals

Chemical Structure : ZN148

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ZN148 (APC148)

货号: PC-27134Not For Human Use, Lab Use Only.

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生物&药学活性

ZN148 (APC148) is a specific, irreversible, zinc-chelating metallo-β-lactamase (MBL) inhibitor with broad activity against Ambler class B enzymes, including NDM, VIM, and IMP, restores the in vitro and in vivo activity of meropenem against multidrug-resistant MBL-producing Enterobacterales.
ZN148 (APC148) potentiates the effect of meropenem against NDM-1-producing Klebsiella pneumoniae in a murine neutropenic peritonitis model.
ZN148 shows no inhibition of the human zinc-containing enzyme glyoxylase II at 500 uM.
ZN148 restored the bactericidal activity of meropenem against an NDM-1-producing K. pneumoniae strain.
ZN148 potentiates the activity of meropenem in vivo with no acute toxicity in vivo.

物理化学性质&存储条件

分子量	511.58
分子式	C26H33N5O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-((bis(pyridin-2-ylmethyl)amino)methyl)-N-methyl-N-((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)nicotinamide

参考文献

1. Ørjan Samuelsen, et al. Antimicrob Agents Chemother. 2020 May 21;64(6):e02415-19.

ZN148 (APC148)

生物&药学活性

物理化学性质&存储条件

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ZN148 (APC148)

生物&药学活性

物理化学性质&存储条件

参考文献

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