ZN-c5 hydrochloride

Chemical Structure : ZN-c5 hydrochloride

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货号: PC-28731Not For Human Use, Lab Use Only.

ZN-c5 hydrochloride is a selective, brain penetrant, orally active estrogen receptor (ER) degrader (SERD) with cellular IC50 of 0.3 nM (MCF-7), binds with high affinity to ERα and ERβ (IC50=0.4 nM and 0.8 nM, respectively).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

ZN-c5 hydrochloride is a selective, brain penetrant, orally active estrogen receptor (ER) degrader (SERD) with cellular IC50 of 0.3 nM (MCF-7), binds with high affinity to ERα and ERβ (IC50=0.4 nM and 0.8 nM, respectively).
ZN-c5 hydrochloride shows excellent cell potency in breast cancer lines and displayed highly favorable in vitro ADME properties across multiple species.
ZN-c5 hydrochloride shows excellent efficacy in multiple brain metastasis breast cancer mouse models.

物理化学性质&存储条件

分子量	470.94
分子式	C26H25ClF2N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(4-((1R,3R)-2-(bicyclo[1.1.1]pentan-1-yl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)-3,5-difluorophenyl)acrylic acid hydrochloride

参考文献

1. Zhang G, et al. J Med Chem. 2025 Jun 12;68(11):11990-12003.

2. Hegde SG, et al. J Med Chem. 2025 Jul 24;68(14):14740-14755.