ZM39923 |CAS:273727-89-2 Probechem Biochemicals

Chemical Structure : ZM39923

CAS No.: 273727-89-2

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ZM39923 (ZM-39923)

货号: PC-43113Not For Human Use, Lab Use Only.

ZM39923 is a potent, selective JAK3 inhibitor with pIC50 of 7.1, also potently inhibits human tissue transglutaminase (TGM2, hTG2) with IC50 of 10 nM.

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10 mg	￥980	In stock
50 mg	￥2680	In stock
100 mg	￥4680	In stock
250 mg		Get quote
1 g		Get quote

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生物&药学活性

ZM39923 is a potent, selective JAK3 inhibitor with pIC50 of 7.1, also potently inhibits human tissue transglutaminase (TGM2, hTG2) with IC50 of 10 nM.
ZM39923 is less potent for EGFR, JAK1 and CDK4 with pIC50 of 5.6, 4.4 and < 5.0, no activity fgor JAK2.
ZM39923 alteres TGM2 activity in polyglutamine-expressing Drosophila model of neurodegeneration and is found to improve survival.
ZM39923 significantly attenuates CCR7-induced Jak3 phosphorylation in metastatic SCCHN cells.

物理化学性质&存储条件

分子量	331.4507
分子式	C23H25NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-

参考文献

1. Lai TS, et al. Chem Biol. 2008 Sep 22;15(9):969-78.

2. Zhang Z, et al. Oncol Lett. 2017 May;13(5):3191-3197.

3. Luo C, et al. Drug Discov Today. 2004 Mar 15;9(6):268-75.

4. Brown GR, et al. Bioorg Med Chem Lett. 2000 Mar 20;10(6):575-9.

ZM39923 (ZM-39923)

生物&药学活性

物理化学性质&存储条件

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ZM39923 (ZM-39923)

生物&药学活性

物理化学性质&存储条件

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