ZM241385 |CAS:139180-30-6 Probechem Biochemicals

Chemical Structure : ZM241385

CAS No.: 139180-30-6

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ZM241385 (ZM-241385;ZM 241385)

货号: PC-45641Not For Human Use, Lab Use Only.

ZM241385 is a potent, non-xanthine A2A-selective adenosine receptor antagonist with rat PC12 binding pIC50 of 9.52.

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10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2380	In stock
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生物&药学活性

ZM241385 is a potent, non-xanthine A2A-selective adenosine receptor (A2AR) antagonist with rat PC12 binding pIC50 of 9.52.
ZM241385 shows low affinity for A3 receptors (pIC50=3.82).
ZM241385 antagonizes vasodilatation of the coronary bed produced by 2-CADO and CGS21680 with pA2 of 8.57 and 9.02, respectively, in guinea-pig isolated Langendorff hearts.
ZM241385 selectively attenuates the mean arterial blood pressure response produced by exogenous adenosine in conscious spontaneously hypertensive rats (3-10 mg/kg, p.o.).

物理化学性质&存储条件

分子量	337.336
分子式	C16H15N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	Phenol, 4-[2-[[7-amino-2-(2-furanyl)[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]amino]ethyl]-

参考文献

1. Poucher SM, et al. Br J Pharmacol. 1995 Jul;115(6):1096-102.

2. Guo D, et al. ChemMedChem. 2014 Apr;9(4):752-61.

3. Poucher SM, et al. J Pharm Pharmacol. 1996 Jun;48(6):601-6.

ZM241385 (ZM-241385;ZM 241385)

生物&药学活性

物理化学性质&存储条件

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ZM241385 (ZM-241385;ZM 241385)

生物&药学活性

物理化学性质&存储条件

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