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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-ZM145
ZM145

Chemical Structure : ZM145

CAS No.:

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ZM145 (pNPS145)

货号: PC-21995Not For Human Use, Lab Use Only.

ZM145 (pNPS145) is a small molecule inhibitor of phospho-BRD4 (pBRD4) with IC50 of 2.5 uM, binds to phospho-NPS (pNPS) and disrupts HPV E2-BRD4 interaction, effectively inhibits HPV ecDNA replication.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ZM145 (pNPS145) is a small molecule inhibitor of phospho-BRD4 (pBRD4) with IC50 of 2.5 uM, binds to phospho-NPS (pNPS) and disrupts HPV E2-BRD4 interaction, effectively inhibits HPV ecDNA replication.

物理化学性质&存储条件

分子量 361.42
分子式 C20H15N3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(2-(6-Hydroxy-1H-indol-3-yl)thiazol-4-yl)-2-methyl-1H-indol-5-ol

参考文献

1. Wu SY, et al. Mol Cell. 2024 Jan 18;84(2):202-220.e15.

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