ZLc002 | nNOS inhibitor | Probechem Biochemicals

Chemical Structure : ZLc002

CAS No.: 308277-46-5

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ZLc002 (ZLc-002, ZLc 002)

货号: PC-35678Not For Human Use, Lab Use Only.

ZLc002 (ZLc-002) is a putative small-molecule inhibitor of nNOS interaction with NOS1AP, disrupts neuronal nitric oxide synthase-NOS1AP interaction in intact cells.

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10 mg	￥1280	In stock
25 mg	￥1980	In stock
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100 mg		Get quote

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生物&药学活性

ZLc002 (ZLc-002) is a putative small-molecule inhibitor of nNOS interaction with NOS1AP, disrupts neuronal nitric oxide synthase-NOS1AP interaction in intact cells.
ZLc002 exhibits anxiolytic-like efficacy in a mouse model of chronic mild stress without altering appetite, general activity, or locomotor activity or interfering with the resting potential of neurons.
ZLc002 also inhibits co-immunoprecipitation of NOS1AP with nNOS in hippocampal cells.
ZLc002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability.
ZLc002 suppresses formalin-evoked inflammatory pain in rats and reduced Fos protein-like immunoreactivity in the lumbar spinal dorsal horn (4-10 mg/kg i.p.).

物理化学性质&存储条件

分子量	231.248
分子式	C10H17NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl (3-methoxy-3-oxopropanoyl)-L-valinate

参考文献

1. Lee WH, et al. Mol Pain. 2018 Jan-Dec;14:1744806918801224.

2. Zhu LJ, et al. Nat Med. 2014 Sep;20(9):1050-4.

ZLc002 (ZLc-002, ZLc 002)

生物&药学活性

物理化学性质&存储条件

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ZLc002 (ZLc-002, ZLc 002)

生物&药学活性

物理化学性质&存储条件

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