ZLDI-8 |CAS:667880-38-8 Probechem Biochemicals

Chemical Structure : ZLDI-8

CAS No.: 667880-38-8

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ZLDI-8 (ZLDI8;IAC-8)

货号: PC-35373Not For Human Use, Lab Use Only.

ZLDI-8 (IAC-8) is a novel Notch signaling pathway inhibitor for Notch activating/cleaving enzyme ADAM-17, significantly decreases the level of NICD and accumulation of NICD in the nucleus.

规格	价格	库存
2 mg	￥1380	In stock
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

ZLDI-8 (IAC-8) is a novel Notch signaling pathway inhibitor for Notch activating/cleaving enzyme ADAM-17, significantly decreases the level of NICD and accumulation of NICD in the nucleus.
ZLDI-8 (IAC-8) exhibits cytotoxic acitviity against MHCC97-H cells with IC50 of 5.32 uM, reduces the expression of pro-survival/anti-apoptosis regulators, Survivin and cIAP1/2, also increases the expression of epithelial marker E-Cadherin and reduces mesenchymal markers N-Cadherin and Vimentin in HCC cells.
ZLDI-8 (IAC-8) significantly disrupted the activity of Notch pathway in HCC cells and inhibits the epithelial-mesenchymal transition (EMT) process of HCC cells.
ZLDI-8 (IAC-8) treatment enhances the susceptibility of HCC cells to Sorafenib, Etoposide, and Paclitaxel both in vitro and in vivo.

物理化学性质&存储条件

分子量	433.526
分子式	C24H23N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((1-(2-(2,4-dimethylphenoxy) ethyl) -2-methyl-1H-indol-3-yl) methylene) -2-thioxodihydropyrimidine-4,6 (1H,5H) -dione

参考文献

1. Zhang Y, et al. Cell Death Dis. 2018 Jul 3;9(7):743.

ZLDI-8 (ZLDI8;IAC-8)

生物&药学活性

物理化学性质&存储条件

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ZLDI-8 (ZLDI8;IAC-8)

生物&药学活性

物理化学性质&存储条件

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