ZLC853 | CDK12/13 inhibitor | Probechem Biochemicals

Chemical Structure : ZLC853

加入收藏

ZLC853 (ZLC-853)

货号: PC-28745Not For Human Use, Lab Use Only.

ZLC853 is a potent, selective, and orally bioavailable covalent inhibitor of CDK12/13 with IC50 of 40.0 nM and 18.2 nM respectively, inhibits VCaP cell proliferation with IC50 of 13.7 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

ZLC853 is a potent, selective, and orally bioavailable covalent inhibitor of CDK12/13 with IC50 of 40.0 nM and 18.2 nM respectively, inhibits VCaP cell proliferation with IC50 of 13.7 nM.
ZLC853 covalently binds and modifies Cys 1039 in CDK12 and Cys 1017 in CDK13.
ZLC853 exhibits high kinase selectivity for CDK12 and CDK13, shows 16- and 36-fold selectivity over other CDKs with exception of CDK7 (IC50=81.75 nM).
ZLC853 does not engage CDK7 covalently in cells.
ZLC853 (100 nM) inhibits Ser 2 phosphorylation of RNA polymerase II, suppresses transcription of DDR genes, and induces apoptosis in VCaP cells.
ZLC853 (5 and 10 mg/kg, p.o., q.d.) inhibits prostate cancer growth in VCaP CRPC mouse model.

物理化学性质&存储条件

分子量	697.84
分子式	C38H45F2N9O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(4-(dimethylamino)piperidin-1-yl)-5-(3-((S)-1-(4-fluorophenyl)ethyl)-1-((1r,4S)-4-(quinazolin-2-ylamino)cyclohexyl)ureido)pyridin-3-yl)-2-fluoroacrylamide

参考文献

1. Zhou K, et al. Acta Pharm Sin B. 2026 Nov;16(11):7554-7572.

ZLC853 (ZLC-853)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

ZLC853 (ZLC-853)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.