ZL192 | FGF13/Nav1.7 inhibitor | Probechem Biochemicals

Chemical Structure : ZL192

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ZL192 (ZL-192)

货号: PC-25070Not For Human Use, Lab Use Only.

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生物&药学活性

ZL192 is a small molecule FGF13 ligand / activator and a positive modulator of FGF13/Nav1.7 complex, stabilizes FGF13/Nav1.7 CTD assembly with EC50 of 28 uM, sensitizes Na+ currents in hIPSC-derived sensory neurons.
ZL192 has no agonist activity against the FGF13R110A/Nav1.7 complex.
ZL192 binds to both FGF13 at Arg110 and Nav1.7 CTD at M1830, binds to FGF13 with SPR KD of 4 μM.
ZL192 exerts regulatory effects on Nav1.7 currents only in HEK-Nav1.7 cells coexpressing FGF13 with EC50 of 8.5 uM.
ZL192 and FGF13 overexpression sensitize Na+ currents in hIPSC-derived sensory neurons and are pronociceptive, without triggering stimuli.
ZL192 exhibits pronociceptive roles that are prevented by in vivo FGF13 silencing and recapitulated in FGF13 overexpression.

物理化学性质&存储条件

分子量	620.80
分子式	C34H48N6O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(acetyl-L-phenylalanyl-L-leucyl)-N-((S)-6-amino-1-oxo-1-(phenylamino)hexan-2-yl)pyrrolidine-2-carboxamide

参考文献

1. Singh AK, et al. J Clin Invest. 2025 Jul 15;135(14):e183749.

ZL192 (ZL-192)

生物&药学活性

物理化学性质&存储条件

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ZL192 (ZL-192)

生物&药学活性

物理化学性质&存储条件

参考文献

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