ZL141 | GSK3β/Nav1.6 inhibitor | Probechem Biochemicals

Chemical Structure : ZL141

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ZL141 (ZL-141)

货号: PC-26654Not For Human Use, Lab Use Only.

ZL141 is a peptidomimetic that disrupts GSK3β/Nav1.6 CTD complex formation with IC50 of 20 uM, does not affect the kinase activity of GSK3β, ZL141 binds to GSK3β with SPR KD of 15.9 uM.

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生物&药学活性

ZL141 is a peptidomimetic that disrupts GSK3β/Nav1.6 CTD complex formation with IC50 of 20 uM, does not affect the kinase activity of GSK3β, ZL141 binds to GSK3β with SPR KD of 15.9 uM.
ZL141 counteracts the modulatory effects of GSK3β on Nav1.6 currents, likely by interfering with the kinase's complex actions on Nav1.6 channels.
ZL141 modulates kinetic properties of Nav1.6 channels.
ZL141 reduces the intrinsic excitability of medium spiny neurons (MSNs) of the nucleus accumbens (NAc) through a GSK3β-dependent mechanism.

物理化学性质&存储条件

分子量	508.62
分子式	C28H36N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	benzyl ((S)-1-(((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-4-methyl-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

参考文献

1. Aditya K Singh, et al. Br J Pharmacol. 2026 Apr 28. doi: 10.1111/bph.70458.

ZL141 (ZL-141)

生物&药学活性

物理化学性质&存储条件

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ZL141 (ZL-141)

生物&药学活性

物理化学性质&存储条件

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