ZL0590 | BRD4 BD1 inhibitor | Probechem Biochemicals

Chemical Structure : ZL0590

CAS No.: 2230496-99-6

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ZL0590 (ZL 0590)

货号: PC-21739Not For Human Use, Lab Use Only.

ZL0590 is a potent, orally active, BRD4 BD1-selective inhibitor with IC50 of 90 nM for human BRD4 BD1.

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5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5580	In stock
100 mg		Get quote

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生物&药学活性

ZL0590 is a potent, orally active, BRD4 BD1-selective inhibitor with IC50 of 90 nM for human BRD4 BD1.
ZL0590 inhibits Poly(I:C)-induced expression of inflammatory genes CIG5 and IL-6 in hSAECs with IC50 of 0.2 and 0.37 uM, respectively.
ZL0590 is 10-fold more selective over BRD4 BD2, BRD2 BD1, and BRD2 BD2, highly selective over other BET members (e.g., BRD3 and BRDT) and non-BET protein (e.g., CBP).
ZL0590 binds selectively to WT BRD4-BD1 but not WT BRD4-BD2 nor E151-mutated BRD4-BD1.
ZL0590 (10 mg/kg, po) blocked poly(I:C)-induced acute airway inflammation in mice.

物理化学性质&存储条件

分子量	512.55
分子式	C23H27F3N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N-[4-[[(2S)-2-(4-morpholinylmethyl)-1-pyrrolidinyl]sulfonyl]phenyl]-N'-[4-(trifluoromethyl)phenyl]-

参考文献

1. Liu Z, et al. J Med Chem. 2022 Feb 10;65(3):2388-2408.

ZL0590 (ZL 0590)

生物&药学活性

物理化学性质&存储条件

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ZL0590 (ZL 0590)

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