ZL006 |CAS:1181226-02-7 Probechem Biochemicals

Chemical Structure : ZL006

CAS No.: 1181226-02-7

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ZL006 (ZL-006;ZL 006)

货号: PC-42162Not For Human Use, Lab Use Only.

ZL006 (ZL 006, ZL006) is a brain penetrant small molecule inhibitor of PSD-95/nNOS interaction that prevents glutamate-induced excitotoxicity and cerebral ischemic damage in vivo.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
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生物&药学活性

ZL006 (ZL 006, ZL-006) is a brain penetrant small molecule inhibitor of PSD-95/nNOS interaction that prevents glutamate-induced excitotoxicity and cerebral ischemic damage in vivo.
ZL006 selectively blocks the ischemia-induced nNOS-PSD-95 association.
ZL006 shows potent neuroprotective activity in vitro and ameliorates focal cerebral ischemic damage in mice and rats subjected to middle cerebral artery occlusion (MCAO) and reperfusion.
ZL006 does not inhibit NMDAR function, catalytic activity of nNOS or spatial memory, and has no effect on aggressive behaviors.

物理化学性质&存储条件

分子量	328.1474
分子式	C14H11Cl2NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 29 mg/mL
Chemical Name/SMILES	Benzoic acid, 4-[[(3,5-dichloro-2-hydroxyphenyl)methyl]amino]-2-hydroxy-

参考文献

1. Zhou L, et al. Nat Med. 2010 Dec;16(12):1439-43.

2. Doucet MV, et al. Neuropsychopharmacology. 2013 Jul;38(8):1575-84.

3. Bach A, et al. Sci Rep. 2015 Jul 16;5:12157.

ZL006 (ZL-006;ZL 006)

生物&药学活性

物理化学性质&存储条件

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ZL006 (ZL-006;ZL 006)

生物&药学活性

物理化学性质&存储条件

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