ZK756326 dihydrochloride

Chemical Structure : ZK756326 dihydrochloride

CAS No.: 1780259-94-0

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货号: PC-23198Not For Human Use, Lab Use Only.

ZK756326 dihydrochloride is a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8, inhibits the binding of the CCR8 ligand I-309 (CCL1) with IC50 of 1.8 uM.

规格	价格	库存
10 mg	￥880	In stock
50 mg	￥1980	In stock
100 mg	￥3280	In stock
250 mg		Get quote

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生物&药学活性

ZK756326 dihydrochloride is a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8, inhibits the binding of the CCR8 ligand I-309 (CCL1) with IC50 of 1.8 uM.
ZK 756326 is a full agonist of CCR8, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1.
ZK 756326 stimulated extracellular acidification in cells expressing human CCR8.
ZK 756326 inhibited human immunodeficiency virus (HIV) fusion of cells expressing CD4 and CCR8

物理化学性质&存储条件

分子量	429.38
分子式	C21H30Cl2N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(4-(3-Phenoxybenzyl)piperazin-1-yl)ethoxy)ethan-1-ol dihydrochloride

参考文献

1. Haskell CA, et al. Mol Pharmacol. 2006 Jan;69(1):309-16.