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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-ZK756326
ZK756326

Chemical Structure : ZK756326

CAS No.: 874911-96-3

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ZK756326 (ZK 756326)

货号: PC-21255Not For Human Use, Lab Use Only.

ZK 756326 is a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8, inhibits the binding of the CCR8 ligand I-309 (CCL1) with IC50 of 1.8 uM.

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10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2180 In stock
100 mg ￥3580 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ZK 756326 is a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8, inhibits the binding of the CCR8 ligand I-309 (CCL1) with IC50 of 1.8 uM.
ZK 756326 is a full agonist of CCR8, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1.
ZK 756326 stimulated extracellular acidification in cells expressing human CCR8.
ZK 756326 inhibited human immunodeficiency virus (HIV) fusion of cells expressing CD4 and CCR8.

物理化学性质&存储条件

分子量 356.47
分子式 C21H28N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2-(4-(3-Phenoxybenzyl)piperazin-1-yl)ethoxy)ethan-1-ol

参考文献

1. Haskell CA, et al. Mol Pharmacol. 2006 Jan;69(1):309-16.

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