ZINC621433144 | D4 agonist | Probechem Biochemicals

Chemical Structure : ZINC621433144

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ZINC621433144 (ZINC 621433144)

货号: PC-20978Not For Human Use, Lab Use Only.

ZINC621433144 is a Gi-biased, high-affinity full agonist of dopamine D4 receptor with Ki of 4.3 nM and cAMP EC50 of 0.18 nM.

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生物&药学活性

ZINC621433144 is a Gi-biased, high-affinity full agonist of dopamine D4 receptor with Ki of 4.3 nM and cAMP EC50 of 0.18 nM.
ZINC621433144 displays no affinity for D2 and D3 receptors.
ZINC621433144 shows EC50 of 0.56 and 2.3 nM in Gi BRET and Arrestin BRET assays, respectively.

物理化学性质&存储条件

分子量	301.43
分子式	C18H27N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N1[C@@H](C)C2=C(C=CC=C2)C1)N[C@H]3CN(C(C)C)C[C@@H]3C

参考文献

1. Jiankun Lyu, et al. Nature. 2019 Feb;566(7743):224-229.

ZINC621433144 (ZINC 621433144)

生物&药学活性

物理化学性质&存储条件

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ZINC621433144 (ZINC 621433144)

生物&药学活性

物理化学性质&存储条件

参考文献

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