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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Focal Adhesion Kinase (FAK)-ZINC40099027
ZINC40099027

Chemical Structure : ZINC40099027

CAS No.: 1211825-25-0

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ZINC40099027 (ZINC 40099027)

货号: PC-73097Not For Human Use, Lab Use Only.

ZINC40099027 is a specific focal adhesion kinase (FAK) activator, actually activates FAK at concentrations as low as 10 nM.

规格 价格 库存 数量
5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4880 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ZINC40099027 is a specific focal adhesion kinase (FAK) activator, actually activates FAK at concentrations as low as 10 nM.
ZINC40099027 (10–1000 nM) dose-dependently activated FAK phosphorylation, without activating Pyk2-Tyr-402 or Src-Tyr-419.
ZINC40099027 (10 nM) increased FAK-Tyr 397 phosphorylation by 12.9%, 19.1%, 31.1% at 1hr, 6hr, 24hr respectively, in treated migrating Caco-2 cells.
ZINC40099027 stimulates Caco-2 cell monolayer wound closure.
ZINC40099027 dose-dependently increased FAK-Tyr-397 phosphorylation with Emax 36.0% in Caco-2 cells.
ZINC40099027 promotes intestinal mucosal healing in a murine ischemic ulcer model, promotes the healing of indomethacin-induced small intestine injury in mice and does not affect murine kidney and liver morphology.

物理化学性质&存储条件

分子量 449.47
分子式 C23H25F3N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-methoxyphenyl)-N-(2-morpholino-5-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamide

参考文献

1. Wang Q, et al. Sci Rep. 2019 Oct 11;9(1):14669.

2. Rashmi, et al. Pharmacol Res Perspect. 2021 Apr;9(2):e00737.

3. Wang Q, et al. ACS Med Chem Lett. 2021 Feb 16;12(3):356-364.

4. Oncel S, et al. Cells. 2021 Apr 15;10(4):908.

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