ZINC17988990 | TRPV5 inhibitor | Probechem Biochemicals

Chemical Structure : ZINC17988990

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ZINC17988990 (ZINC 17988990)

货号: PC-73351Not For Human Use, Lab Use Only.

ZINC 17988990 is a potent, selective inhibitor of TRPV5 mediated currents, inhibits rbTRPV5/hTRPV5 with IC50 of 106/177 nM, showing marked selectivity for TRPV5 over TRPV6.

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生物&药学活性

ZINC 17988990 is a potent, selective inhibitor of TRPV5 mediated currents, inhibits rbTRPV5/hTRPV5 with IC50 of 106/177 nM, showing marked selectivity for TRPV5 over TRPV6.
ZINC 17988990 shows no activity on other TRP channels (TRPV1, TRPV3, TRPV4 and TRPM8) at 1-3 uM, and moderate inhibition on TRPV3 and TRPM8 at >10 uM.
ZINC17988990 (10 uM) fully inhibited Ca2+ signals elicited by application of external Ca2+ in HEK293 cells transfected with TRPV5, but had no effect in cells expressing TRPV6.

物理化学性质&存储条件

分子量	461.492
分子式	C24H19N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-oxo-5-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)methyl 3-(3-oxo-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)propanoate

参考文献

1. Taylor Et Hughes, et al. Elife. 2019 Oct 25;8:e49572.

ZINC17988990 (ZINC 17988990)

生物&药学活性

物理化学性质&存储条件

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ZINC17988990 (ZINC 17988990)

生物&药学活性

物理化学性质&存储条件

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