欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-GPCR-Mas-related G protein-coupled receptor (MRGPR)-ZINC16991592
ZINC16991592

Chemical Structure : ZINC16991592

CAS No.: 422274-45-1

加入收藏

ZINC16991592 (ZINC1592)

货号: PC-38067Not For Human Use, Lab Use Only.

ZINC16991592 (ZINC1592) is a selective MRGPRX2 antagonist with Ki of 189 nM.

规格 价格 库存 数量
2 mg ￥2580 In stock
5 mg ￥3980 In stock
10 mg ￥5980 In stock
25 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: 98.58% (HPLC) Select Batch:

生物&药学活性

ZINC16991592 (ZINC1592) is a selective MRGPRX2 antagonist with Ki of 189 nM.
ZINC16991592 completely inhibits the degranulation of human cord blood-derived MCs (hCMCs) induced by basic secretagogues and pseudoallergic drug, icatibant (Cat. PC-45267).
ZINC16991592 markedly inhibits the de novo synthesis of substance P (SP)-induced prostaglandin D2 in hCMCs.
ZINC16991592 inhibit p42/44 mitogen-activated protein kinase signal in hCMCs activated by SP.

物理化学性质&存储条件

分子量 269.322
分子式 C14H11N3OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(pyridin-2-ylmethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one

参考文献

1. Can Cao, et al. Nature. 2021 Dec;600(7887):170-175.

2. Hiroyuki Ogasawara, et al. J Leukoc Biol. 2019 Nov;106(5):1069-1077.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: