ZINC13407541 | FGF23 inhibitor | Probechem Biochemicals

Chemical Structure : ZINC13407541

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ZINC13407541 (ZINC 13407541)

货号: PC-72719Not For Human Use, Lab Use Only.

ZINC13407541 is a small molecule antagonist for FGF23, inhibits FGF-23 signaling with IC50 of 0.45 uM.

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生物&药学活性

ZINC13407541 is a small molecule antagonist for FGF23, inhibits FGF-23 signaling with IC50 of 0.45 uM.
ZINC13407541 binds to FGF-23 and disrupts its interaction with the FGFR1/α-KL complex, inhibits FGF-23 activation of the FGFR/a-KL receptor complex.
ZINC13407541 caused significant -60 and 100% inhibition of FGF-23 stimulation of ERK reporter activity at 2.5 and 10 μM, respectively, in HEK293T cells, did not inhibit FGFR activation of these FGF ligands.
ZINC13407541 significantly increased serum phosphate, PTH, and 1,25(OH)2D, decreased serum abundance of FGF-23 by about 35% in Dmp1-null mice.

物理化学性质&存储条件

分子量	213.28
分子式	C14H15NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-((E)-styryl)cyclopent-1-ene-1-carbaldehyde oxime

参考文献

1. Xiao Z, et al. Sci Signal. 2016 Nov 22;9(455):ra113.

2. Xiao Z, et al. Mol Pharmacol. 2022 Mar 26:MOLPHARM-AR-2021-000471.

ZINC13407541 (ZINC 13407541)

生物&药学活性

物理化学性质&存储条件

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ZINC13407541 (ZINC 13407541)

生物&药学活性

物理化学性质&存储条件

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