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首页-小分子抑制剂&激动剂-GPCR-mGluR-ZINC12427628
ZINC12427628

Chemical Structure : ZINC12427628

CAS No.: 937954-56-8

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ZINC12427628 (ZINC 12427628, Compound '628)

货号: PC-62819Not For Human Use, Lab Use Only.

ZINC12427628 (Compound '628) is a potent, selective positive allosteric modulator of M2 mAChR with EC50 of 1.1 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    ZINC12427628 (Compound '628) is a potent, selective positive allosteric modulator of M2 mAChR with EC50 of 1.1 uM.
    ZINC12427628 enhances the binding of N-methyl scopolamine (NMS), while sparing the endogenous agonist acetylcholine, slows the dissociation rate of NMS from the M2 mAChR by 50-fold.
    The selective allostery between '628 and NMS was retained in membranes from adult rat hypothalamus and in neonatal rat cardiomyocytes.

    物理化学性质&存储条件

    分子量 448.501
    分子式 C22H20N6O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-acetamidophenyl)-2-((4-allyl-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)thio)acetamide

    参考文献

    1. Korczynska M, et al. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2419-E2428.

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