ZIKV inhibitor K22 |CAS:2141978-86-9 Probechem Biochemicals

Chemical Structure : ZIKV inhibitor K22

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ZIKV inhibitor K22

货号: PC-35651Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

ZIKV inhibitor K22 is a small molecule that exerts a potent antiviral activity against a broad range of coronaviruses by targeting membrane-bound viral RNA replication, effectively inhibits ZIKV with IC50 of 2.1 uM (48 h p.i).
ZIKV inhibitor K22 inhibits several members of the family Flaviviridae, blocks replication of ZIKV, yellow fever virus (YFV), Japanese encephalitis virus (JEV), West Nile virus (WNV), as well as to a certain extent, Usutu virus (USUV), Wesselsbron virus (WESSV), HCV and bovine viral diarrhea virus (BVDV) with IC50s <10 uM.
ZIKV inhibitor K22 acts on early post-entry stages of coronavirus replication and to target membrane-bound viral RNA synthesis.

物理化学性质&存储条件

分子量	505.412
分子式	C27H25BrN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-N-(3-(4-(4-bromophenyl)-4-hydroxypiperidin-1-yl)-3-oxo-1-phenylprop-1-en-2-yl)benzamide

参考文献

1. García-Nicolás O, et al. Antimicrob Agents Chemother. 2018 Sep 4. pii: AAC.01206-18.