ZHSI-1 hydrochloride

Chemical Structure : ZHSI-1 hydrochloride

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货号: PC-21423Not For Human Use, Lab Use Only.

ZHSI-1 hydrochloride is a novel inhibitor of Enterovirus 71 (EV71) and Coxsackie A16 (CVA16) replication, interacts with 3D and potently inhibits EV71-induced cell death with IC50 of 3.27 uM.

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生物&药学活性

ZHSI-1 hydrochloride is a novel inhibitor of Enterovirus 71 (EV71) and Coxsackie A16 (CVA16) replication, interacts with 3D and potently inhibits EV71-induced cell death with IC50 of 3.27 uM.
ZHSI-1 significantly reduced EV71 and CVA16 RNA replication and viral titers in a dose-dependent manner in infected RD cells.
ZHSI-1 significantly inhibits the localization of 3D and PI4KB on the lysosomal surface and inhibited the colocalization of 3D and RagB.
ZHSI-1 also inhibits EV71-induced pyroptosis in EV71-infected RD cells.
ZHSI-1 hydrochloride (30 mg/kg) inhibits EV71 replication and viral pathogenesis in EV71-695F-infected mice, efficiently reduces the levels of EV71-695F RNA in the liver, brain, and muscles of mice.

物理化学性质&存储条件

分子量	329.83
分子式	C17H20ClN5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N2-isopropyl-6-methyl-N4-(quinolin-6-yl)pyrimidine-2,4-diamine hydrochloride

参考文献

1. Wang X, et al. J Cell Biol. 2023 Dec 4;222(12):e202303108.