ZHAWOC21026 | Paramyxovirus inhibitor | Probechem Biochemicals

Chemical Structure : ZHAWOC21026

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ZHAWOC21026 (ZHAWOC 21026)

货号: PC-73387Not For Human Use, Lab Use Only.

ZHAWOC21026 is a highly potent, host-specific small-molecule inhibitor of paramyxovirus (Canine distemper virus, CDV IC50=3.2 nM) and pneumovirus (RSV, IC50=31 nM) replication.

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生物&药学活性

ZHAWOC21026 is a highly potent, host-specific small-molecule inhibitor of paramyxovirus (Canine distemper virus, CDV IC50=3.2 nM) and pneumovirus (RSV, IC50=31 nM) replication.
ZHAWOC21026 demonstrated highly potent inhibitory activity against A75/17-CDV, PIV-5, RSV, and NiV in corresponding cells (IC50<80 nM).
ZHAWOC21026 inhibits the replication via the RdRp complex but, however in a host-directed manner, which in turn prohibits the emergence of resistant mutants.

物理化学性质&存储条件

分子量	372.483
分子式	C20H24N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)oxy)-N-methyl-N-(4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide

参考文献

1. Shrestha N, et al. mBio. 2021 Dec 21;12(6):e0262121.

ZHAWOC21026 (ZHAWOC 21026)

生物&药学活性

物理化学性质&存储条件

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ZHAWOC21026 (ZHAWOC 21026)

生物&药学活性

物理化学性质&存储条件

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