ZH07 | Dual Mcl-1/Bfl-1 inhibitor | Probechem Biochemicals

Chemical Structure : ZH07

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ZH07 (Dual Mcl-1/Bfl-1 inhibitor 24)

货号: PC-73236Not For Human Use, Lab Use Only.

ZH07 (Dual Mcl-1/Bfl-1 inhibitor 24) is a potent, selective dual Mcl-1 and Bfl-1 inhibitor, binds both Mcl-1 and Bfl-1 with Ki of 97 nM and 100 nM, respectively.

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生物&药学活性

ZH07 (Dual Mcl-1/Bfl-1 inhibitor 24) is a potent, selective dual Mcl-1 and Bfl-1 inhibitor, binds both Mcl-1 and Bfl-1 with Ki of 97 nM and 100 nM, respectively.
ZH07 displays appreciable selectivity (>250-fold) over Bcl-2/Bcl-xL.
ZH07 induces dose-dependent disruption of interactions between BL-Bim and endogenous Mcl-1 and Bfl-1, without affecting the complexes between BL-Bim and Bcl-2 or Bcl-xL.
ZH07 demonstrates on-target cellular activity in model lymphoma cell lines.

物理化学性质&存储条件

分子量	567.763
分子式	C30H37N3O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((4-(4-(tert-butyl)benzyl)piperazine)-1-sulfonamido)-5-(phenethylthio)benzoic acid

参考文献

1. Xuexin Feng, et al. European Journal of Medicinal Chemistry 236 (2022) 114327

2. Karson J Kump, et al. J Med Chem. 2020 Mar 12;63(5):2489-2510.

ZH07 (Dual Mcl-1/Bfl-1 inhibitor 24)

生物&药学活性

物理化学性质&存储条件

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ZH07 (Dual Mcl-1/Bfl-1 inhibitor 24)

生物&药学活性

物理化学性质&存储条件

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