ZGN-1061 |CAS:2082752-83-6 Probechem Biochemicals

Chemical Structure : ZGN-1061

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ZGN-1061 (Aclimostat;ZGN1061)

货号: PC-63184Not For Human Use, Lab Use Only.

ZGN-1061 (Aclimostat) is a novel potent, selective Methionine aminopeptidase 2 (MetAP2) inhibitor being investigated for treatment of diabetes and obesity.

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生物&药学活性

ZGN-1061 (Aclimostat) is a novel potent, selective Methionine aminopeptidase 2 (MetAP-2) inhibitor being investigated for treatment of diabetes and obesity.
ZGN-1061 reduces body weight in diet-induced obese (DIO) insulin-resistant mice, also produced improvements in metabolic parameters, including plasma glucose and insulin, and, in HepG2 cells, initiated gene changes similar to beloranib.
ZGN-1061 does not increase coagulation markers in dogs and ZGN-1061 has a greatly improved safety profile in rats relative to beloranib.

物理化学性质&存储条件

分子量	478.63
分子式	C26H42N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3- methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl 3-[2-(morpholin-4-yl)ethyl]azetidine-1-carboxylate

参考文献

1. Burkey BF, et al. J Pharmacol Exp Ther. 2018 Feb 28. pii: jpet.117.246272.

ZGN-1061 (Aclimostat;ZGN1061)

生物&药学活性

物理化学性质&存储条件

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ZGN-1061 (Aclimostat;ZGN1061)

生物&药学活性

物理化学性质&存储条件

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