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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Thyroid Hormone Receptor (THR)-ZG-2585
ZG-2585

Chemical Structure : ZG-2585

CAS No.:

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ZG-2585 (ZG2585)

货号: PC-27331Not For Human Use, Lab Use Only.

ZG-2585 is a potent and selective, orally active Thyroid hormone receptor β (THRβ) agonist with EC50 of 1.24 uM, shows 5-fold selectivity against THRα, improves body weight, hepatic steatosis and lipid accumulation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ZG-2585 is a potent and selective, orally active Thyroid hormone receptor β (THRβ) agonist with EC50 of 1.24 uM, shows 5-fold selectivity against THRα, improves body weight, hepatic steatosis and lipid accumulation.

物理化学性质&存储条件

分子量 400.21
分子式 C16H15Cl2N3O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)benzoyl)glycine

参考文献

1. Wu Y, et al. J Med Chem. 2026 Jul 16. doi: 10.1021/acs.jmedchem.6c01599.

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