ZFP-B34

Chemical Structure : ZFP-B34

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货号: PC-25323Not For Human Use, Lab Use Only.

ZFP-B34 is a potent, dual inhibitor of sphingosine kinase 1/2 (SphK1/2), effectively inhibits cell proliferation, cell cycle progression, and migration in TNBC cells.

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生物&药学活性

ZFP-B34 is a potent, dual inhibitor of sphingosine kinase 1/2 (SphK1/2), effectively inhibits cell proliferation, cell cycle progression, and migration in TNBC cells.
ZFP-B34 induces reactive oxygen species (ROS) production and mitochondrial depolarization, leading to mitochondrial dysfunction.
ZFP-B34 also inhibits the activation of Akt-mammalian target of rapamycin (mTOR) while inducing c-Jun N-terminal kinase (JNK) activation in TNBC cells.
ZFP-B34 effectively inhibits the growth of 4T1 allografts in mice.

物理化学性质&存储条件

分子量	469.51
分子式	C23H30F3N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1,2,4-Oxadiazole, 5-(3-azetidinylmethyl)-3-[4-(8-nonen-1-yloxy)phenyl]-, 2,2,2-trifluoroacetate (1:1)

参考文献

1. Bingqing Cui, et al. Biol Pharm Bull. 2025;48(8):1172-1184.

ZFP-B34

生物&药学活性

物理化学性质&存储条件

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ZFP-B34

生物&药学活性

物理化学性质&存储条件

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